Transfected Stable Cell Lines
Reliable | High-Performance | Wide Rage
Precision reporter, kinase, immune receptor, biosimilar, Cas9, and knockout stable cell lines for diverse applications.
Cat. No. : CDFR007828
| Cat. No. | CDFR007828 |
| Description | NativeORF clone of Rattus norvegicus arginine-rich, mutated in early stage tumors (Armet) as transfection-ready DNA NM_001108183.1 |
| Product Type | cDAN Clone |
| Gene Abbr | Manf |
| Species | Rat |
| Vector | pCMV6Entry |
| Target Gene | MANF |
| Background | The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related. [provided by RefSeq, Apr 2014] |
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