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Rat Madd cDNA Clone(NM_053585.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR013307

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Gene Information

Cat. No. CDFR013307
Description NativeORF clone of Rattus norvegicus MAP-kinase activating death domain (Madd) as transfection-ready DNA NM_053585.1
Product Type cDAN Clone
Gene Abbr Madd
Species Rat
Vector pCMV6Entry
Target Gene MADD
Background Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
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