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Rat Lrp5 cDNA Clone(NM_001106321.2)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR006065

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Gene Information

Cat. No. CDFR006065
Description NativeORF clone of Rattus norvegicus low density lipoprotein receptor-related protein 5 (Lrp5) as transfection-ready DNA NM_001106321.2
Product Type cDAN Clone
Gene Abbr Lrp5
Species Rat
Size 10 ug
Vector pCMV6Entry
Target Gene LRP5
Background This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
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