Rat Litaf cDNA Clone(NM_001105735.2)

Name: Rat Litaf cDNA Clone(NM_001105735.2)
SKU: CDFR005471
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR005471

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Product Information

Gene Information

Cat. No.	CDFR005471
Description	NativeORF clone of Rattus norvegicus lipopolysaccharide-induced TNF factor (Litaf) as transfection-ready DNA NM_001105735.2
Product Type	cDAN Clone
Gene Abbr	Litaf
Species	Rat
Size	10 ug
Vector	pCMV6Entry

Target Gene

LITAF

Background

Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppressor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014]

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