Transfected Stable Cell Lines
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Precision reporter, kinase, immune receptor, biosimilar, Cas9, and knockout stable cell lines for diverse applications.
Cat. No. : CDCR008810
| Cat. No. | CDCR008810 |
| Product Type | ORF clone |
| Gene Abbr | LITAF |
| Species | Mouse |
| Host Cell | Bacterial: Spectinomycin |
| Source | Bacterial: Spectinomycin |
| ORF Size | 2240bp |
| Size | 1ug |
| Format | Clear Liquid |
| Vector | pORF |
| Buffer | 10mM Tris-HCI, 1mM EDTA, pH8.0 |
| Warning | pORF-mLitaf ORF Vector is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. |
| Storage | 1 year when stored at -20°C or lower in a non-frost free freezer. |
| Target Gene | LITAF |
| Background | Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppressor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014] |
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