Rat Ireb2 cDNA Clone(NM_022863.2)

Name: Rat Ireb2 cDNA Clone(NM_022863.2)
SKU: CDFR012137
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR012137

Inquire for Price

Product Information

Gene Information

Cat. No.	CDFR012137
Description	NativeORF clone of Rattus norvegicus iron responsive element binding protein 2 (Ireb2) as transfection-ready DNA NM_022863.2
Product Type	cDAN Clone
Gene Abbr	Ireb2
Species	Rat
Vector	pCMV6Entry

Target Gene

IREB2

Background

The protein encoded by this gene is an RNA-binding protein that acts to regulate iron levels in the cells by regulating the translation and stability of mRNAs that affect iron homeostasis under conditions when iron is depleted. When iron levels are low, this protein binds to iron-responsive elements (IRES), stem-loop structures located either in the 5' or 3' UTRs. Binding to the 5' UTR represses translation, while binding to the 3' UTR inhibits mRNA degradation. When iron is found in the cell, this protein is degraded in a F-box and leucine rich repeat protein 5-dependent manner. Variants in this gene have been associated with lung cancer and chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]

Quick Inquiry

Q & A

Customer Reviews

Ask a Question

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

Question *

Name

Country *

Email *

Write a Review

Write a review of your use of Biogene products and services in your research. Your review can help your fellow researchers make informed purchasing decisions.

Product Name *

Catalog Name *

Rating

Needs improvement

Satisfaction

General satisfaction

Very satisfaction

Product Review Title *

Summary *