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Rat Ireb2 ORF Clone(NM_022863.2)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR379184

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Product Information

Gene Information

Cat. No. CDCR379184
Product Type ORF Clone
Gene Abbr Ireb2
Species Rat
Tag C-terminal Myc-DDK
ORF Size 2892 bp
Vector pCMV6-Entry
Target Gene IREB2
Background The protein encoded by this gene is an RNA-binding protein that acts to regulate iron levels in the cells by regulating the translation and stability of mRNAs that affect iron homeostasis under conditions when iron is depleted. When iron levels are low, this protein binds to iron-responsive elements (IRES), stem-loop structures located either in the 5' or 3' UTRs. Binding to the 5' UTR represses translation, while binding to the 3' UTR inhibits mRNA degradation. When iron is found in the cell, this protein is degraded in a F-box and leucine rich repeat protein 5-dependent manner. Variants in this gene have been associated with lung cancer and chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
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