Transfected Stable Cell Lines
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Precision reporter, kinase, immune receptor, biosimilar, Cas9, and knockout stable cell lines for diverse applications.
Cat. No. : CDFR012228
| Cat. No. | CDFR012228 |
| Description | NativeORF clone of Rattus norvegicus indoleamine 2,3-dioxygenase 1 (Ido1) as transfection-ready DNA NM_023973.1 |
| Product Type | cDAN Clone |
| Gene Abbr | Ido1 |
| Species | Rat |
| Vector | pCMV6Entry |
| Target Gene | IDO1 |
| Background | This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011] |
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