Rat IL6ST ORF clone(NM_001008725.3)

Name: Rat IL6ST ORF clone(NM_001008725.3)
SKU: CDCL184906
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCL184906

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Product Information

Gene Information

Cat. No.	CDCL184906
Description	ORF Clone of Rattus norvegicus interleukin 6 signal transducer DNA.
Product Type	ORF clone
Gene Abbr	IL6ST
Species	Rat
ORF Size	2757bp
Vector	pMD18-T
Warning	This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Storage	store at -20°C

Target Gene

IL6ST

Background

The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014]

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