Rat Hexb cDNA Clone(NM_001011946.1)

Name: Rat Hexb cDNA Clone(NM_001011946.1)
SKU: CDFR002375
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR002375

Inquire for Price

Product Information

Gene Information

Cat. No.	CDFR002375
Description	NativeORF clone of Rattus norvegicus hexosaminidase B (Hexb) as transfection-ready DNA NM_001011946.1
Product Type	cDAN Clone
Gene Abbr	Hexb
Species	Rat
Size	10 ug
Vector	pCMV6Entry

Target Gene

HEXB

Background

Hexosaminidase B is the beta subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Beta subunit gene mutations lead to Sandhoff disease (GM2-gangliosidosis type II). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

Quick Inquiry

Q & A

Customer Reviews

Ask a Question

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

Question *

Name

Country *

Email *

Write a Review

Write a review of your use of Biogene products and services in your research. Your review can help your fellow researchers make informed purchasing decisions.

Product Name *

Catalog Name *

Rating

Needs improvement

Satisfaction

General satisfaction

Very satisfaction

Product Review Title *

Summary *