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Mouse Hexb cDNA Clone(NM_010422.2)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFL005647

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Product Information

Gene Information

Cat. No. CDFL005647
Product Type cDNA clone
Gene Abbr Hexb
Species Mouse
Size 10 ug
Vector pCMV6Entry
Target Gene HEXB
Background Hexosaminidase B is the beta subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Beta subunit gene mutations lead to Sandhoff disease (GM2-gangliosidosis type II). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]
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