Rat Fzd6 cDNA Clone(NM_001130536.1)

Name: Rat Fzd6 cDNA Clone(NM_001130536.1)
SKU: CDFR009705
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR009705

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Product Information

Gene Information

Cat. No.	CDFR009705
Description	NativeORF clone of Rattus norvegicus frizzled homolog 6 (Drosophila) (Fzd6) as transfection-ready DNA NM_001130536.1
Product Type	cDAN Clone
Gene Abbr	Fzd6
Species	Rat
Vector	pCMV6Entry

Target Gene

FZD6

Background

This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.[provided by RefSeq, Aug 2011]

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