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Mouse Fzd6 ORF Clone(NM_008056.3)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR244772

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Product Information

Gene Information

Cat. No. CDCR244772
Product Type ORF Clone
Gene Abbr Fzd6
Species Mouse
Tag C-terminal TurboGFP
ORF Size 2130 bp
Size 10 ug
Vector pCMV6-AC-GFP
Target Gene FZD6
Background This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.[provided by RefSeq, Aug 2011]
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