Rat Fgfr3 cDNA Clone(NM_053429.1)

Name: Rat Fgfr3 cDNA Clone(NM_053429.1)
SKU: CDFR013172
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR013172

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Product Information

Gene Information

Cat. No.	CDFR013172
Description	NativeORF clone of Rattus norvegicus fibroblast growth factor receptor 3 (Fgfr3) as transfection-ready DNA NM_053429.1
Product Type	cDAN Clone
Gene Abbr	Fgfr3
Species	Rat
Vector	pCMV6Entry

Target Gene

FGFR3

Background

This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. [provided by RefSeq, Aug 2017]

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