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Rat Fancd2 cDNA Clone(NM_001001719.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR001177

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Gene Information

Cat. No. CDFR001177
Description NativeORF clone of Rattus norvegicus Fanconi anemia, complementation group D2 (Fancd2) as transfection-ready DNA NM_001001719.1
Product Type cDAN Clone
Gene Abbr Fancd2
Species Rat
Size 10 ug
Vector pCMV6Entry
Target Gene FANCD2
Background The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homology-directed DNA repair. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
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