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Mouse Fancd2 ORF Clone(NM_001033244.3)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR232009

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Product Information

Gene Information

Cat. No. CDCR232009
Product Type ORF Clone
Gene Abbr Fancd2
Species Mouse
Tag C-terminal TurboGFP
ORF Size 4353 bp
Size 10 ug
Vector pCMV6-AC-GFP
Target Gene FANCD2
Background The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homology-directed DNA repair. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
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