Rat F3 cDNA Clone(NM_013057.2)

Name: Rat F3 cDNA Clone(NM_013057.2)
SKU: CDFR010860
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR010860

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Product Information

Gene Information

Cat. No.	CDFR010860
Description	NativeORF clone of Rattus norvegicus coagulation factor III (thromboplastin, tissue factor) (F3) as transfection-ready DNA NM_013057.2
Product Type	cDAN Clone
Gene Abbr	F3
Species	Rat
Vector	pCMV6Entry

Target Gene

Background

This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces, for example, on monocytes. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. Platelets and monocytes have been shown to express this coagulation factor under procoagulatory and proinflammatory stimuli, and a major role in HIV-associated coagulopathy has been described. Platelet-dependent monocyte expression of coagulation factor III has been described to be associated with Coronavirus Disease 2019 (COVID-19) severity and mortality. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Aug 2020]

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