Rat Ercc5 cDNA Clone(NM_001106910.1)

Name: Rat Ercc5 cDNA Clone(NM_001106910.1)
SKU: CDFR006636
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR006636

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Product Information

Gene Information

Cat. No.	CDFR006636
Description	NativeORF clone of Rattus norvegicus excision repair cross-complementing rodent repair deficiency, complementation group 5 (Ercc5) as transfection-ready DNA NM_001106910.1
Product Type	cDAN Clone
Gene Abbr	Ercc5
Species	Rat
Size	10 ug
Vector	pCMV6Entry

Target Gene

ERCC5

Background

This gene encodes a single-strand specific DNA endonuclease that makes the 3' incision in DNA excision repair following UV-induced damage. The protein may also function in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair. Mutations in this gene cause xeroderma pigmentosum complementation group G (XP-G), which is also referred to as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and increased susceptibility for skin cancer development following UV exposure. Some patients also develop Cockayne syndrome, which is characterized by severe growth defects, cognitive disability, and cachexia. Read-through transcription exists between this gene and the neighboring upstream BIVM (basic, immunoglobulin-like variable motif containing) gene. [provided by RefSeq, Feb 2011]

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