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Rat Erbb4 ORF Clone(NM_021687.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR378781

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Product Information

Gene Information

Cat. No. CDCR378781
Product Type ORF Clone
Gene Abbr Erbb4
Species Rat
Tag C-terminal Myc-DDK
ORF Size 3927 bp
Vector pCMV6-Entry
Target Gene ERBB4
Background This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
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