Rat Ebp ORF Clone(NM_057137.1)

Name: Rat Ebp ORF Clone(NM_057137.1)
SKU: CDCR380778
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCR380778

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Product Information

Gene Information

Cat. No.	CDCR380778
Product Type	ORF Clone
Gene Abbr	Ebp
Species	Rat
Tag	C-terminal Myc-DDK
ORF Size	693 bp
Vector	pCMV6-Entry

Target Gene

EBP

Background

The protein encoded by this gene is an integral membrane protein of the endoplasmic reticulum. It is a high affinity binding protein for the antiischemic phenylalkylamine Ca2+ antagonist [3H]emopamil and the photoaffinity label [3H]azidopamil. It is similar to sigma receptors and may be a member of a superfamily of high affinity drug-binding proteins in the endoplasmic reticulum of different tissues. This protein shares structural features with bacterial and eukaryontic drug transporting proteins. It has four putative transmembrane segments and contains two conserved glutamate residues which may be involved in the transport of cationic amphiphilics. Another prominent feature of this protein is its high content of aromatic amino acid residues (>23%) in its transmembrane segments. These aromatic amino acid residues have been suggested to be involved in the drug transport by the P-glycoprotein. Mutations in this gene cause Chondrodysplasia punctata 2 (CDPX2; also known as Conradi-Hunermann syndrome). [provided by RefSeq, Jul 2008]

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