Rat Depdc5 cDNA Clone(NM_001107229.1)

Name: Rat Depdc5 cDNA Clone(NM_001107229.1)
SKU: CDFR006952
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR006952

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Product Information

Gene Information

Cat. No.	CDFR006952
Description	NativeORF clone of Rattus norvegicus DEP domain containing 5 (Depdc5) as transfection-ready DNA NM_001107229.1
Product Type	cDAN Clone
Gene Abbr	Depdc5
Species	Rat
Size	10 ug
Vector	pCMV6Entry

Target Gene

DEPDC5

Background

This gene encodes a member of the IML1 family of proteins involved in G-protein signaling pathways. The mechanistic target of rapamycin complex 1 (mTORC1) pathway regulates cell growth by sensing the availability of nutrients. The protein encoded by this gene is a component of the GATOR1 (GAP activity toward Rags) complex which inhibits the amino acid-sensing branch of the mTORC1 pathway. Mutations in this gene are associated with autosomal dominant familial focal epilepsy with variable foci. A single nucleotide polymorphism in an intron of this gene has been associated with an increased risk of hepatocellular carcinoma in individuals with chronic hepatitis C virus infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

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