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Mouse Depdc5 cDNA Clone(NM_001170567.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFG021181

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Gene Information

Cat. No. CDFG021181
Product Type cDNA clone
Gene Abbr Depdc5
Species Mouse
ORF Size 4776bp
Size 10 ug
Vector pCMV6Entry
Target Gene DEPDC5
Background This gene encodes a member of the IML1 family of proteins involved in G-protein signaling pathways. The mechanistic target of rapamycin complex 1 (mTORC1) pathway regulates cell growth by sensing the availability of nutrients. The protein encoded by this gene is a component of the GATOR1 (GAP activity toward Rags) complex which inhibits the amino acid-sensing branch of the mTORC1 pathway. Mutations in this gene are associated with autosomal dominant familial focal epilepsy with variable foci. A single nucleotide polymorphism in an intron of this gene has been associated with an increased risk of hepatocellular carcinoma in individuals with chronic hepatitis C virus infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
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