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Rat Dbi cDNA Clone(NM_031853.4)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR012972

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Gene Information

Cat. No. CDFR012972
Description NativeORF clone of Rattus norvegicus diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein) (Dbi) as transfection-ready DNA NM_031853.4
Product Type cDAN Clone
Gene Abbr Dbi
Species Rat
Vector pCMV6Entry
Target Gene DBI
Background This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
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