Rat Cyp27b1 cDNA Clone(NM_053763.1)

Name: Rat Cyp27b1 cDNA Clone(NM_053763.1)
SKU: CDFR013445
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR013445

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Product Information

Gene Information

Cat. No.	CDFR013445
Description	NativeORF clone of Rattus norvegicus cytochrome P450, family 27, subfamily b, polypeptide 1 (Cyp27b1), nuclear gene encoding mitochondrial protein as transfection-ready DNA NM_053763.1
Product Type	cDAN Clone
Gene Abbr	Cyp27b1
Species	Rat
Vector	pCMV6Entry

Target Gene

CYP27B1

Background

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position. This reaction synthesizes 1alpha,25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I. [provided by RefSeq, Jul 2008]

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