Rat Cyp1a1 cDNA Clone(NM_012540.2)

Name: Rat Cyp1a1 cDNA Clone(NM_012540.2)
SKU: CDFR010360
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR010360

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Product Information

Gene Information

Cat. No.	CDFR010360
Description	NativeORF clone of Rattus norvegicus cytochrome P450, family 1, subfamily a, polypeptide 1 (Cyp1a1) as transfection-ready DNA NM_012540.2
Product Type	cDAN Clone
Gene Abbr	Cyp1a1
Species	Rat
Vector	pCMV6Entry

Target Gene

CYP1A1

Background

This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]

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