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Rat Cyp1a1 ORF Clone(NM_012540.2)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR377287

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Product Information

Gene Information

Cat. No. CDCR377287
Product Type ORF Clone
Gene Abbr Cyp1a1
Species Rat
Tag C-terminal Myc-DDK
ORF Size 1575 bp
Vector pCMV6-Entry
Target Gene CYP1A1
Background This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]
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