Rat Calm2 cDNA Clone(NM_017326.1)

Name: Rat Calm2 cDNA Clone(NM_017326.1)
SKU: CDFR011040
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR011040

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Product Information

Gene Information

Cat. No.	CDFR011040
Description	NativeORF clone of Rattus norvegicus calmodulin 2 (Calm2) as transfection-ready DNA NM_017326.1
Product Type	cDAN Clone
Gene Abbr	Calm2
Species	Rat
Vector	pCMV6Entry

Target Gene

CALM2

Background

This gene is a member of the calmodulin gene family. There are three distinct calmodulin genes dispersed throughout the genome that encode the identical protein, but differ at the nucleotide level. Calmodulin is a calcium binding protein that plays a role in signaling pathways, cell cycle progression and proliferation. Several infants with severe forms of long-QT syndrome (LQTS) who displayed life-threatening ventricular arrhythmias together with delayed neurodevelopment and epilepsy were found to have mutations in either this gene or another member of the calmodulin gene family (PMID:23388215). Mutations in this gene have also been identified in patients with less severe forms of LQTS (PMID:24917665), while mutations in another calmodulin gene family member have been associated with catecholaminergic polymorphic ventricular tachycardia (CPVT)(PMID:23040497), a rare disorder thought to be the cause of a significant fraction of sudden cardiac deaths in young individuals. Pseudogenes of this gene are found on chromosomes 10, 13, and 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]

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