Rat COL18A1 ORF clone(NM_053489.2)

Name: Rat COL18A1 ORF clone(NM_053489.2)
SKU: CDCH383700
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCH383700

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Product Information

Gene Information

Cat. No.	CDCH383700
Product Type	ORF clone
Gene Abbr	COL18A1
Species	Rat
Host Cell	Bacterial
Source	Bacterial
ORF Size	5007bp
Size	1ug
Format	Clear Liquid
Vector	pORF
Buffer	10mM Tris-HCI, 1mM EDTA, pH8.0
Warning	pORF-rCol18a1 ORF Vector is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information.
Storage	1 year when stored at -20°C or lower in a non-frost free freezer.

Target Gene

COL18A1

Background

This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

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