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Rat Brd2 ORF Clone(NM_212495.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR382154

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Gene Information

Cat. No. CDCR382154
Product Type ORF Clone
Gene Abbr Brd2
Species Rat
Tag C-terminal Myc-DDK
ORF Size 2397 bp
Vector pCMV6-Entry
Target Gene BRD2
Background This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene. [provided by RefSeq, Dec 2010]
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