Transfected Stable Cell Lines
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Precision reporter, kinase, immune receptor, biosimilar, Cas9, and knockout stable cell lines for diverse applications.
Cat. No. : CDFR009520
| Cat. No. | CDFR009520 |
| Description | NativeORF clone of Rattus norvegicus BRCA1/BRCA2-containing complex, subunit 3 (Brcc3) as transfection-ready DNA NM_001127300.1 |
| Product Type | cDAN Clone |
| Gene Abbr | Brcc3 |
| Species | Rat |
| Vector | pCMV6Entry |
| Target Gene | BRCC3 |
| Background | This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jun 2011] |
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