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Mouse Brcc3 cDNA Clone(NM_145956.4)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFL001958

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Gene Information

Cat. No. CDFL001958
Product Type cDNA clone
Gene Abbr Brcc3
Species Mouse
Size 10 ug
Vector pCMV6Entry
Target Gene BRCC3
Background This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jun 2011]
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