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Rat Bad ORF Clone(NM_022698.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR379149

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Gene Information

Cat. No. CDCR379149
Product Type ORF Clone
Gene Abbr Bad
Species Rat
Tag C-terminal Myc-DDK
ORF Size 618 bp
Vector pCMV6-Entry
Target Gene BAD
Background The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL (B-cell lymphoma-extra large) and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq, Dec 2019]
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