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Rat Atp2a2 ORF Clone(NM_001110139.2)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR376284

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Gene Information

Cat. No. CDCR376284
Product Type ORF Clone
Gene Abbr Atp2a2
Species Rat
Tag C-terminal Myc-DDK
ORF Size 2994 bp
Vector pCMV6-Entry
Target Gene ATP2A2
Background This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of the skeletal muscle. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Other types of mutations in this gene have been associated with various forms of muscular dystrophies. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2019]
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