Rat Ar ORF Clone(NM_012502.1)

Name: Rat Ar ORF Clone(NM_012502.1)
SKU: CDCR377411
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCR377411

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Product Information

Gene Information

Cat. No.	CDCR377411
Product Type	ORF Clone
Gene Abbr	Ar
Species	Rat
Tag	C-terminal Myc-DDK
ORF Size	2709 bp
Vector	pCMV6-Entry

Target Gene

Background

The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedy's disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017]

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