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Rat Aire cDNA Clone(NM_001106379.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR006117

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Gene Information

Cat. No. CDFR006117
Description NativeORF clone of Rattus norvegicus autoimmune regulator (Aire) as transfection-ready DNA NM_001106379.1
Product Type cDAN Clone
Gene Abbr Aire
Species Rat
Size 10 ug
Vector pCMV6Entry
Target Gene AIRE
Background This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED). [provided by RefSeq, Jun 2012]
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