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Rat Agrn cDNA Clone(NM_175754.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR014862

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Gene Information

Cat. No. CDFR014862
Description NativeORF clone of Rattus norvegicus agrin (Agrn) as transfection-ready DNA NM_175754.1
Product Type cDAN Clone
Gene Abbr Agrn
Species Rat
Vector pCMV6Entry
Target Gene AGRN
Background This gene encodes one of several proteins that are critical in the development of the neuromuscular junction (NMJ), as identified in mouse knock-out studies. The encoded protein contains several laminin G, Kazal type serine protease inhibitor, and epidermal growth factor domains. Additional post-translational modifications occur to add glycosaminoglycans and disulfide bonds. In one family with congenital myasthenic syndrome affecting limb-girdle muscles, a mutation in this gene was found. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]
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