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Rat Actl6a cDNA Clone(NM_001039033.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR004675

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Gene Information

Cat. No. CDFR004675
Description NativeORF clone of Rattus norvegicus actin-like 6A (Actl6a) as transfection-ready DNA NM_001039033.1
Product Type cDAN Clone
Gene Abbr Actl6a
Species Rat
Size 10 ug
Vector pCMV6Entry
Target Gene ACTL6A
Background This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described. [provided by RefSeq, Jul 2008]
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