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Rat Aanat cDNA Clone(NM_012818.2)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR010675

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Gene Information

Cat. No. CDFR010675
Description NativeORF clone of Rattus norvegicus arylalkylamine N-acetyltransferase (Aanat) as transfection-ready DNA NM_012818.2
Product Type cDAN Clone
Gene Abbr Aanat
Species Rat
Vector pCMV6Entry
Target Gene AANAT
Background The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
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