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Mouse Aanat ORF Clone(NM_009591.3)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR247517

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Gene Information

Cat. No. CDCR247517
Product Type ORF Clone
Gene Abbr Aanat
Species Mouse
Tag C-terminal TurboGFP
ORF Size 618 bp
Size 10 ug
Vector pCMV6-AC-GFP
Target Gene AANAT
Background The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
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