Panoply™ Human ITGB1BP1 Over-expressing Stable Cell Line

Name: Panoply™ Human ITGB1BP1 Over-expressing Stable Cell Line
SKU: CSC-SC007802
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-SC007802

Host Cell : HEK293 (CHO and other cell types are also available) Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Gene Information

Cat. No.	CSC-SC007802
Description	Using Creative Biogene's proprietary lentiviral vectors, we subclone the target gene into lentivector, generate the lentivirus particles, sequentially infect the cell line HEK293 (other cell types are also available according to your requirements), and select the clones constantly expressing target gene at high level.
Target Gene	ITGB1BP1
Gene Species	Homo sapiens (Human)
Host Cell	HEK293 (CHO and other cell types are also available)
Host Cell Species	Species varies
Applications	1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Disease research
Size	2 × 10^6 cells / vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry Ice

Revival

Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	ITGB1BP1 integrin beta 1 binding protein 1 [ Homo sapiens ]
Gene Symbol	ITGB1BP1
Synonyms	ICAP1; ICAP1A; ICAP1B; ICAP-1A; ICAP-1B; ICAP-1alpha
Gene Description	integrin beta 1 binding protein 1
GeneID	9270
Uni ProtID	O14713
mRNA Refseq	NM_004763.3
Protein Refseq	NP_004754.1
Chromosome Location	2p25.2
Function	protein binding;
MIM	607153

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Q & A

Customer Reviews

Customer Q&As

What alterations will occur during the integrin-mediated cell-matrix adhesion?

A: Acts as a guanine nucleotide dissociation inhibitor (GDI) by regulating Rho family GTPases during integrin-mediated cell matrix adhesion.

What happens when the cell adheres to fibronectin?

A: It reduces the level of active GTP-bound form of both CDC42 and RAC1 GTPases upon cell adhesion to fibronectin.

How can the ITGB1BP1 gene be maintained in an inactive cytoplasmic pool?

A: ITGB1BP1 gene stimulates the release of active CDC42 from the membranes to maintain it in an inactive cytoplasmic pool.

How does this ITGB1BP1 gene lead to increased myoblast migration on laminin?

A: It participates in the translocation of the Rho-associated protein kinase ROCK1 to membrane ruffles at cell leading edges of the cell membrane, leading to an increase of myoblast cell migration on laminin.

Does this ITGB1BP1 gene play a role in bone mineralization at the late stages of osteoblast differentiation?

A: IITGB1BP1 stimulates the release of active CDC42 from the membranes to maintain it in an inactive cytoplasmic pool.

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