Panoply™ Human ITGB1BP1 Knockdown Stable Cell Line

Name: Panoply™ Human ITGB1BP1 Knockdown Stable Cell Line
SKU: CSC-DC007802
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-DC007802

Host Cell : HEK293 (Hela and other cell types are also available) Validation : Real-Time RCR

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Cell Line Information

Safety and Packaging

Gene Information

Cat. No.	CSC-DC007802
Description	Creative Biogene's Knockdown Cell Lines are target specific shRNA lentivirus transduced cells. The percent knockdown levels range from 75-99% depending on the gene, as evaluated by Real-Time RCR. Cells are rigorously qualified and mycoplasma free.
Target Gene	ITGB1BP1
Host Cell	HEK293 (Hela and other cell types are also available)
Host Cell Species	Homo sapiens (Human)
Applications	(1) Studying gene functions (2) Studying gene interactions and signaling pathways (3) Target validation and drug discovery (4) Designing diseases models
Size	>1 × 10⁶ cells / vial
Stability	Validated for at least 10 passages
Validation	Real-Time RCR
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid Nitrogen
Shipping	Dry Ice

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	ITGB1BP1 integrin beta 1 binding protein 1 [ Homo sapiens ]
Gene Symbol	ITGB1BP1
Synonyms	ICAP1; ICAP1A; ICAP1B; ICAP-1A; ICAP-1B; ICAP-1alpha
Gene Description	integrin beta 1 binding protein 1
GeneID	9270
Uni ProtID	O14713
mRNA Refseq	NM_004763.3
Protein Refseq	NP_004754.1
Chromosome Location	2p25.2
Function	protein binding;
MIM	607153

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Q & A

Customer Reviews

Customer Q&As

How does this ITGB1BP1 gene form fiber adhesions?

A: ITGB1BP1 gene participates in the translocation of the Rho-associated protein kinase ROCK1 to membrane ruffles at cell leading edges of the cell membrane, leading to an increase of myoblast cell migration on laminin.

What processes can the adhesion structure of the ITGB1BP1 gene be responsible for?

A: ITGB1BP1 gene plays a role in bone mineralization at a late stage of osteoblast differentiation.

In what processes does this ITGB1BP1 gene function in?

A: The gene ITGB1BP1 modulates the dynamic formation of focal adhesions into fibrillar adhesions, which are adhesive structures responsible for fibronectin deposition and fibrillogenesis.

How does the ITGB1BP1 gene generate a negative regulator?

A: ITGB1BP1 plays a role in blood vessel development and acts as a negative regulator of angiogenesis by attenuating endothelial cell proliferation and migration, lumen formation and sprouting angiogenesis by promoting AKT phosphorylation and inhibiting ERK1/2 phosphorylation through activation of the Notch signaling pathway.

Can this ITGB1BP1 protein promote the transcriptional activity of the MYC promoter?

A: The ITGB1BP1 protein promoters transcriptional activity of the MYC promoter.

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