Panoply™ Human CDK2 Knockdown Stable Cell Line

Name: Panoply™ Human CDK2 Knockdown Stable Cell Line
SKU: CSC-DC002869
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-DC002869

Host Cell : HEK293 (Hela and other cell types are also available) Validation : Real-Time RCR

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Cell Line Information

Safety and Packaging

Gene Information

Cat. No.	CSC-DC002869
Description	Creative Biogene's Knockdown Cell Lines are target specific shRNA lentivirus transduced cells. The percent knockdown levels range from 75-99% depending on the gene, as evaluated by Real-Time RCR. Cells are rigorously qualified and mycoplasma free.
Target Gene	CDK2
Host Cell	HEK293 (Hela and other cell types are also available)
Host Cell Species	Homo sapiens (Human)
Applications	(1) Studying gene functions (2) Studying gene interactions and signaling pathways (3) Target validation and drug discovery (4) Designing diseases models
Size	>1 × 10⁶ cells / vial
Stability	Validated for at least 10 passages
Validation	Real-Time RCR
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid Nitrogen
Shipping	Dry Ice

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	CDK2 cyclin-dependent kinase 2 [ Homo sapiens ]
Gene Symbol	CDK2
Synonyms	p33(CDK2)
Gene Description	cyclin-dependent kinase 2
GeneID	1017
Uni ProtID	P24941
mRNA Refseq	NM_001798.3
Protein Refseq	NP_001789.2
Chromosome Location	12q13
Function	ATP binding; cyclin binding; cyclin-dependent protein kinase activity; cyclin-dependent protein kinase activity; contributes_to histone kinase activity; metal ion binding; protein binding; protein kinase activity;
Pathway	APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem; Activation of ATR in response to replication stress, organism-specific biosystem; Activation of the pre-replicative complex, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; BARD1 signaling events, organism-specific biosystem; CDK-mediated phosphorylation and removal of Cdc6, organism-specific biosystem; Cell Cycle, organism-specific biosystem;
MIM	116953

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Q & A

Customer Reviews

Customer Q&As

What is CDK？

A: CDKs, or cyclin-dependent kinases, are a set of Ser/Thr kinase systems that correspond to the cell cycle progression.

What is the role of CDK?

A: Various CDKs are activated alternately along the cell cycle chronotope to phosphorylate the corresponding substrates and keep the cell cycle events in order.

What is the role of cyclin-dependent protein kinase?

A: Cyclin-dependent protein kinases, a group of serine/threonine protein kinases, CDK drives the cell cycle through chemotaxis on serine/threonine proteins and, in synergy with cyclin, is an important factor in cell cycle regulation.

How does CDK work in the cell?

A: CDK can bind to cyclin to form a heterodimer, where CDK is the catalytic subunit and cyclin is the regulatory subunit. Different cyclin-CDK complexes, through CDK activity, catalyze the phosphorylation of different substrates, while achieving the advancement and transformation of different phases of the cell cycle.

The activity of CDK depends on the regulation of what substance?

A: CDK activity depends on the sequential expression of its positive regulatory subunit cyclin and the concentration of its negative regulatory subunit CKI (cyclin dependent kinase inhibitor, CDK inhibitor). Also, CDK activity is regulated by phosphorylation and dephosphorylation, as well as by oncogenes and oncogenes.

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