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Nos2 Knockout Mouse Liver Cells

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Cat.No.
CSC-RK0152
Background
Nitric oxide synthase, inducible (iNOS) is an enzyme that in humans is encoded by the NOS2 gene. Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
Growth Properties
Adherent
Host Cell
Liver cells
Ship
Dry ice
Gene Information
Official Symbol
Nos2
Synonyms
NOS2; nitric oxide synthase 2, inducible; nitric oxide synthase, inducible; MAC-NOS; NOS type II; inducible NOS; macrophage NOS; inducible NO synthase; inducible nitric oxide synthase; peptidyl-cysteine S-nitrosylase NOS2; nitric oxide synthase 2, inducible, macrophage; iNOS; Nos-2; Nos2a; i-NOS; NOS-II;
Gene ID
Pathway
Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Arginine and proline metabolism, organism-specific biosystem; Arginine and proline metabolism, conserved biosystem; Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem;
Function
FMN binding; Hsp90 protein binding; NADP binding; arginine binding; cAMP-dependent protein kinase regulator activity; calmodulin binding; flavin adenine dinucleotide binding; heme binding; iron ion binding; metal ion binding; nitric-oxide synthase activity; nitric-oxide synthase activity; oxidoreductase activity; protein binding; protein homodimerization activity; protein homodimerization activity; tetrahydrobiopterin binding;

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