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Mouse Upf1 ORF Clone(NM_030680.2)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR262999

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Gene Information

Cat. No. CDCR262999
Product Type ORF Clone
Gene Abbr Upf1
Species Mouse
Tag C-terminal TurboGFP
ORF Size 3341 bp
Vector pCMV6-AC-GFP
Target Gene UPF1
Background This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
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