Mouse Tbk1 ORF clone (NM_019786.4)

Name: Mouse Tbk1 ORF clone (NM_019786.4)
SKU: CDCH088730
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCH088730

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Product Information

Gene Information

Cat. No.	CDCH088730
Description	Mus musculus TANK-binding kinase 1 (Tbk1), mRNA.
Product Type	ORF clone
Gene Abbr	Tbk1
Species	Mouse
ORF Size	2190bp
Format	purified plasmid
Vector	pDONR
Warning	Please note that the protein for this clone has been annotated or predicted in the UNIPROT database to have a signal peptide. Placing a tag at the N-terminus of this protein may result in loss of the signal peptide function.

Target Gene

TBK1

Background

The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. The protein is also an important kinase for antiviral innate immunity response. [provided by RefSeq, Sep 2021]

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