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Mouse Psen2 ORF Clone(NM_001128605.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR237300

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Product Information

Gene Information

Cat. No. CDCR237300
Product Type ORF Clone
Gene Abbr Psen2
Species Mouse
Tag C-terminal Myc-DDK
ORF Size 1346 bp
Size 10 ug
Vector pCMV6-Entry
Target Gene PSEN2
Background Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008]
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