Mouse PLAT ORF clone(NM_008872.2)

Name: Mouse PLAT ORF clone(NM_008872.2)
SKU: CDCL185742
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCL185742

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Product Information

Gene Information

Cat. No.	CDCL185742
Description	ORF Clone of Mus musculus plasminogen activator, tissue DNA.
Product Type	ORF clone
Gene Abbr	PLAT
Species	Mouse
ORF Size	1680bp
Vector	pGEM-T
Warning	This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Storage	store at -20°C

Target Gene

PLAT

Background

This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

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