Transfected Stable Cell Lines
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Cat. No. : CDCL139847
| Cat. No. | CDCL139847 |
| Description | Mus musculus neuron-glia-CAM-related cell adhesion molecule (Nrcam), transcript variant 2, mRNA. |
| Product Type | ORF clone |
| Gene Abbr | Nrcam |
| Species | Mouse |
| ORF Size | 3561bp |
| Format | purified plasmid |
| Vector | pDONR |
| Warning | Please note that the protein for this clone has been annotated or predicted in the UNIPROT database to have a signal peptide. Placing a tag at the N-terminus of this protein may result in loss of the signal peptide function. |
| Target Gene | NRCAM |
| Background | Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
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