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Mouse NF2 ORF clone (NM_016418.5)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCL137831

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Product Information

Gene Information

Cat. No. CDCL137831
Description Homo sapiens neurofibromin 2 (merlin) (NF2), transcript variant 2, mRNA.
Product Type ORF clone
Gene Abbr NF2
Species Human
ORF Size 1773bp
Format purified plasmid
Vector pDONR
Warning Please note that the protein for this clone has been annotated or predicted in the UNIPROT database to have a signal peptide. Placing a tag at the N-terminus of this protein may result in loss of the signal peptide function.
Target Gene NF2
Background This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that link cytoskeletal components with proteins in the cell membrane. The encoded protein is involved in regulation of contact-dependent inhibition of cell proliferation and functions in cell-cell adhesion and transmembrane signaling. The encoded protein has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics, and proteins involved in regulating ion transport. Disruption of this protein's function has been implicated in tumorigenesis and metastasis. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. [provided by RefSeq, May 2022]
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