Mouse Kctd1 ORF clone (NM_001142731.1)

Name: Mouse Kctd1 ORF clone (NM_001142731.1)
SKU: CDCL123409
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCL123409

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Product Information

Gene Information

Cat. No.	CDCL123409
Description	Mus musculus potassium channel tetramerisation domain containing 1 (Kctd1), transcript variant 1, mRNA.
Product Type	ORF clone
Gene Abbr	Kctd1
Species	Mouse
ORF Size	2586bp
Format	purified plasmid
Vector	pDONR
Warning	Please note that the protein for this clone has been annotated or predicted in the UNIPROT database to have a signal peptide. Placing a tag at the N-terminus of this protein may result in loss of the signal peptide function.

Target Gene

KCTD1

Background

This gene encodes a protein containing a BTB (Broad-complex, tramtrack and bric a brac), also known as a POZ (POxvirus and zinc finger) protein-protein interaction domain. The encoded protein negatively regulates the AP-2 family of transcription factors and the Wnt signaling pathway. A mechanism for the modulation of Wnt signaling has been proposed in which the encoded protein enhances ubiquitination and degradation of the beta-catenin protein. Mutations in this gene have been identified in Scalp-ear-nipple (SEN) syndrome. [provided by RefSeq, May 2017]

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